Aim. To compare the pharmacokinetics and pharmacodynamics of herbal ointment Liu-He-Dan (LHD) and micron LHD (MLHD)\r\nin rats with acute pancreatitis (AP). Methods. Twenty rats were allocated into normal, AP, LHD, andMLHDgroups. LHD orMLHD\r\nwas applied on ratsââ?¬â?¢ abdomens. Plasma levels of emodin, rhein, aloe emodin, physcion, and chrysophanol were determined by high\r\nperformance liquid chromatographyââ?¬â?mass spectrometryââ?¬â?mass spectrometry (HPLC-MS-MS) at different time points, and the\r\npharmacokinetic parameters were calculated. Serumamylase, TNF-a, IL-6, and IL-10 levels, and the pancreatic pathological scores\r\nwere determined at 48 h after LHD or MLHD treatment. Results. T1/2a and area under the curve (AUC) of emodin in the MLHD\r\ngroup were lower than those in the LHD group, while T1/2a and AUC of aloe emodin in the MLHD group were higher than\r\nthose in the LHD group (P < 0.05). T1/2a and Tmax of physcion in the MLHD group were significantly shorter than those in the\r\nLHD group (P < 0.05). Compared with the AP group, the amylase, malondialdehyde (MDA), TNF-a, and IL-6 levels decreased\r\nsignificantly after three days of treatment in LHD and MLHD groups, while the levels of superoxide dismutase (SOD), TNF-a,\r\nand the pancreatic pathological score, were similar. The pharmacodynamic parameters between the LHD and MLHD groups were\r\nsimilar. Conclusion.MLHD had better pharmacokinetics than, and similar pharmacodynamics to, LHD in the management of rats\r\nwith AP, which indicated thatMLHDmight be substituted for LHD in the treatment ofAP and thus reduce the amount ofmedicinal\r\nherbs used.
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